The Titans Week 5 game against the Bills appears after reports of another positive coronavirus case for a Titans player in further doubt.
An outbreak within the Titans organization last week resulted in the week 4 game against the Steelers being postponed until the end of this month.
Mike Vrabel's team has yet to return to their facility after numerous positive tests. On Thursday, the NFL Network and ESPN reported a new instance of a player who has signed COVID-19.
Additionally, an inconclusive positive test on Wednesday was confirmed to be clearly positive, meaning Tennessee has infected 12 players and nine employees with the virus since Sept. 24.
While other teams have reported individual or few cases, the large number of Titans has led to an NFL investigation into the possible cause of the outbreak.
Tennessee, which started 3-0, will do the 4-0 bills in Nashville on Sunday. However, since it was unable to train at its facility, it is likely that the game will have to be postponed. That will cause problems with the NFL's schedule as the Titans got a reunion in Week 4 when their game against the Steelers couldn't take place.
Should the bills run off this week, their next game will be a pivotal Thursday Night Football showdown with a Chiefs team playing their third game in 11 days. The defending Super Bowl champion played the Patriots on Monday, a day later than planned, as both teams had positive COVID-19 tests.
Stephon Gilmore became the second high profile Pats player to return a positive test on Wednesday after quarterback Cam Newton did so last week. However, there were reports that every Patriots player tested negative when the latest results were returned on Thursday.